Assay Detail
Binding
CHEMBL3131493
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant 5-lipoxygenase using arachidonic acid as substrate preincubated for 10 mins before substrate addition measured after 10 mins by HPLC analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL215) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.53 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.00 |
| CHEMBL3125444 | — | — | 1 | 5.70 |
| CHEMBL1950045 | HYDROXYTYROSOL | 3.0 | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93 | ZILEUTON | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3125444 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1950045 | HYDROXYTYROSOL | IC50 | = | 13000.0 | nM | 4.89 |