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Assay Detail

CHEMBL3131507

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Functional
Antiviral activity against HCV1b Con1 infected in human HuH7 cells assessed as inhibition of viral replication after 4 days by luciferase reporter gene assay
ChEMBL ↗
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Hepacivirus hominis
Cell Type Huh-7
Confidence 1 — Organism
Curated By Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗
Type ORGANISM
Organism Hepacivirus hominis

Publication

Discovery of ABT-267, a pan-genotypic inhibitor of HCV NS5A.
DeGoey DA, Randolph JT, Liu D, Pratt J, Hutchins C, Donner P, Krueger AC, Matulenko M, Patel S, Motter CE, Nelson L, Keddy R, Tufano M, Caspi DD, Krishnan P, Mistry N, Koev G, Reisch TJ, Mondal R, Pilot-Matias T, Gao Y, Beno DW, Maring CJ, Molla A, Dumas E, Campbell A, Williams L, Collins C, Wagner R, Kati WM.
J Med Chem (2014) 57 : 2047 -2057
PubMed 24400777 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 37 10.01 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3127112 — — 1 11.00
CHEMBL3127332 — — 1 10.96
CHEMBL3127323 — — 1 10.96
CHEMBL3127337 — — 1 10.92
CHEMBL3127111 — — 1 10.52
CHEMBL3127316 — — 1 10.52
CHEMBL3127109 — — 1 10.49
CHEMBL3127315 — — 1 10.40
CHEMBL3127338 — — 1 10.38
CHEMBL3127310 — — 1 10.30
CHEMBL3127313 — — 1 10.27
CHEMBL3127333 — — 1 10.16
CHEMBL3127318 — — 1 10.12
CHEMBL3127311 — — 1 10.07
CHEMBL3127339 — — 1 10.05
CHEMBL3127330 — — 1 10.02
CHEMBL3127314 — — 1 9.97
CHEMBL3127312 — — 1 9.87
CHEMBL3127110 — — 1 9.85
CHEMBL3127334 — — 1 9.68
CHEMBL3127331 — — 1 9.65
CHEMBL3127335 — — 1 9.40
CHEMBL3127319 — — 1 8.18
CHEMBL3127336 — — 1 6.55
CHEMBL3127327 — — 1 -
CHEMBL3127322 — — 1 -
CHEMBL3127325 — — 1 -
CHEMBL3127329 — — 1 -
CHEMBL3127108 — — 1 -
CHEMBL3127324 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3127112 — EC50 = 0.01 nM 11.00
CHEMBL3127332 — EC50 = 0.011 nM 10.96
CHEMBL3127323 — EC50 = 0.011 nM 10.96
CHEMBL3127337 — EC50 = 0.012 nM 10.92
CHEMBL3127111 — EC50 = 0.03 nM 10.52
CHEMBL3127316 — EC50 = 0.03 nM 10.52
CHEMBL3127109 — EC50 = 0.032 nM 10.49
CHEMBL3127315 — EC50 = 0.04 nM 10.40
CHEMBL3127338 — EC50 = 0.042 nM 10.38
CHEMBL3127310 — EC50 = 0.05 nM 10.30
CHEMBL3127313 — EC50 = 0.054 nM 10.27
CHEMBL3127333 — EC50 = 0.069 nM 10.16
CHEMBL3127318 — EC50 = 0.076 nM 10.12
CHEMBL3127311 — EC50 = 0.086 nM 10.07
CHEMBL3127339 — EC50 = 0.09 nM 10.05
CHEMBL3127330 — EC50 = 0.095 nM 10.02
CHEMBL3127314 — EC50 = 0.106 nM 9.97
CHEMBL3127312 — EC50 = 0.134 nM 9.87
CHEMBL3127110 — EC50 = 0.14 nM 9.85
CHEMBL3127334 — EC50 = 0.211 nM 9.68
CHEMBL3127331 — EC50 = 0.226 nM 9.65
CHEMBL3127335 — EC50 = 0.4 nM 9.40
CHEMBL3127319 — EC50 = 6.54 nM 8.18
CHEMBL3127336 — EC50 = 282.0 nM 6.55
CHEMBL3127113 — EC50 = 0.002 nM -
CHEMBL3127328 — EC50 = 0.0022 nM -
CHEMBL3127326 OMBITASVIR EC50 = 0.005 nM -
CHEMBL3127107 — EC50 = 0.006 nM -
CHEMBL3127321 — EC50 = 0.0062 nM -
CHEMBL3127317 — EC50 = 0.0068 nM -
CHEMBL3127320 — EC50 = 0.0071 nM -
CHEMBL3127324 — EC50 = 0.0079 nM -
CHEMBL3127108 — EC50 = 0.008 nM -
CHEMBL3127329 — EC50 = 0.0084 nM -
CHEMBL3127325 — EC50 = 0.0087 nM -
CHEMBL3127322 — EC50 = 0.0088 nM -
CHEMBL3127327 — EC50 = 0.0088 nM -