Assay Detail
Binding
CHEMBL3131699
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Inhibition of full-length wild-type HCV NS3 protease
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Achiral pyrazinone-based inhibitors of the hepatitis C virus NS3 protease and drug-resistant variants with elongated substituents directed toward the S2 pocket.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 6.44 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | 2.0 | 1 | 10.05 |
| CHEMBL231813 | TELAPREVIR | 4.0 | 1 | 7.82 |
| CHEMBL3125634 | — | — | 1 | 6.96 |
| CHEMBL3125628 | — | — | 1 | 6.92 |
| CHEMBL3125629 | — | — | 1 | 6.85 |
| CHEMBL3125633 | — | — | 1 | 6.80 |
| CHEMBL3125619 | — | — | 1 | 6.60 |
| CHEMBL3125618 | — | — | 1 | 6.54 |
| CHEMBL3125632 | — | — | 1 | 6.54 |
| CHEMBL3125631 | — | — | 1 | 6.48 |
| CHEMBL3125451 | — | — | 1 | 6.42 |
| CHEMBL3125635 | — | — | 1 | 6.41 |
| CHEMBL3125621 | — | — | 1 | 6.41 |
| CHEMBL3125453 | — | — | 1 | 6.40 |
| CHEMBL3125620 | — | — | 1 | 6.36 |
| CHEMBL3125454 | — | — | 1 | 6.36 |
| CHEMBL3125623 | — | — | 1 | 6.27 |
| CHEMBL3125630 | — | — | 1 | 6.25 |
| CHEMBL3125452 | — | — | 1 | 6.22 |
| CHEMBL3125637 | — | — | 1 | 6.18 |
| CHEMBL3125626 | — | — | 1 | 6.16 |
| CHEMBL3125624 | — | — | 1 | 6.09 |
| CHEMBL3125625 | — | — | 1 | 5.96 |
| CHEMBL3125627 | — | — | 1 | 5.72 |
| CHEMBL3125622 | — | — | 1 | 5.68 |
| CHEMBL1222749 | — | — | 1 | 5.42 |
| CHEMBL3125636 | — | — | 1 | 5.21 |
| CHEMBL3125638 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL297884 | CILUPREVIR | Ki | = | 0.089 | nM | 10.05 |
| CHEMBL231813 | TELAPREVIR | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL3125634 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL3125628 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL3125629 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL3125633 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL3125619 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL3125618 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3125632 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL3125631 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL3125451 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL3125635 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3125621 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL3125453 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL3125620 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3125454 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL3125623 | — | Ki | = | 540.0 | nM | 6.27 |
| CHEMBL3125630 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL3125452 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL3125637 | — | Ki | = | 660.0 | nM | 6.18 |
| CHEMBL3125626 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL3125624 | — | Ki | = | 810.0 | nM | 6.09 |
| CHEMBL3125625 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3125627 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL3125622 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL1222749 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL3125636 | — | Ki | = | 6200.0 | nM | 5.21 |
| CHEMBL3125638 | — | Ki | = | 7100.0 | nM | 5.15 |