Assay Detail
Binding
CHEMBL3132035
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Binding affinity to Hepatitis C virus genotype 1b IRES RNA subdomain 2a assessed as conformational change by cyanine dye-based FRET assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis C virus subtype 1b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Hepatitis C virus translation inhibitors targeting the internal ribosomal entry site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.30 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223720 | — | — | 1 | 6.22 |
| CHEMBL223608 | — | — | 1 | 5.47 |
| CHEMBL3126104 | — | — | 1 | 5.20 |
| CHEMBL427101 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223720 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL223608 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL3126104 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL427101 | — | EC50 | = | 50000.0 | nM | 4.30 |