Assay Detail
Functional
CHEMBL3132228
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Antimalarial activity against Plasmodium falciparum 3D7 assessed as growth inhibition after 3 days by HRP2 based ELISA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and study of cytotoxic activity of 1,2,4-trioxane- and egonol-derived hybrid molecules against Plasmodium falciparum and multidrug-resistant human leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.27 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088548 | — | — | 1 | 9.52 |
| CHEMBL2088546 | — | — | 1 | 9.49 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 9.09 |
| CHEMBL3125599 | — | — | 1 | 8.64 |
| CHEMBL470981 | EGONOL | — | 1 | 4.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088548 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL2088546 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL3125599 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL470981 | EGONOL | IC50 | = | 25436.0 | nM | 4.59 |