Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL3132373

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of HIV1 recombinant protease expressed in Escherichia coli using Abz-Ala-Arg-Val-Nle-Tyr(NO2)-Glu-Ala-Nle-NH2 as substrate by FRET assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Protease (CHEMBL2366517)
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Semi-synthesis of acylated triterpenes from olive-oil industry wastes for the development of anticancer and anti-HIV agents.
Parra A, Martin-Fonseca S, Rivas F, Reyes-Zurita FJ, Medina-O'Donnell M, Martinez A, Garcia-Granados A, Lupiañez JA, Albericio F.
Eur J Med Chem (2014) 74 : 278 -301
PubMed 24480359 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 5.35 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL502586 1 6.51
CHEMBL3126478 1 6.40
CHEMBL320364 1 6.25
CHEMBL318169 1 6.16
CHEMBL3126474 1 6.10
CHEMBL3126455 1 5.85
CHEMBL3126461 1 5.72
CHEMBL3126468 1 5.72
CHEMBL3126466 1 5.64
CHEMBL3126454 1 5.50
CHEMBL486822 ACETYL OLEANOLIC ACID 1 5.47
CHEMBL3126467 1 5.46
CHEMBL3126453 1 5.41
CHEMBL3126463 1 5.28
CHEMBL3126465 1 4.85
CHEMBL3126456 1 4.84
CHEMBL3126462 1 4.81
CHEMBL3126457 1 4.56
CHEMBL1797017 1 4.51
CHEMBL168 OLEANOLIC_ACID 1 4.24
CHEMBL201515 MASLINIC ACID 1 4.20
CHEMBL3126460 1 4.14
CHEMBL3126458 1 -
CHEMBL3126459 1 -
CHEMBL3126473 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL502586 IC50 = 310.0 nM 6.51
CHEMBL3126478 IC50 = 400.0 nM 6.40
CHEMBL320364 IC50 = 560.0 nM 6.25
CHEMBL318169 IC50 = 700.0 nM 6.16
CHEMBL3126474 IC50 = 800.0 nM 6.10
CHEMBL3126455 IC50 = 1400.0 nM 5.85
CHEMBL3126461 IC50 = 1900.0 nM 5.72
CHEMBL3126468 IC50 = 1900.0 nM 5.72
CHEMBL3126466 IC50 = 2300.0 nM 5.64
CHEMBL3126454 IC50 = 3200.0 nM 5.50
CHEMBL486822 ACETYL OLEANOLIC ACID IC50 = 3400.0 nM 5.47
CHEMBL3126467 IC50 = 3500.0 nM 5.46
CHEMBL3126453 IC50 = 3900.0 nM 5.41
CHEMBL3126463 IC50 = 5200.0 nM 5.28
CHEMBL3126465 IC50 = 14200.0 nM 4.85
CHEMBL3126456 IC50 = 14300.0 nM 4.84
CHEMBL3126462 IC50 = 15600.0 nM 4.81
CHEMBL3126457 IC50 = 27500.0 nM 4.56
CHEMBL1797017 IC50 = 31200.0 nM 4.51
CHEMBL168 OLEANOLIC_ACID IC50 = 57700.0 nM 4.24
CHEMBL201515 MASLINIC ACID IC50 = 62700.0 nM 4.20
CHEMBL3126460 IC50 = 73000.0 nM 4.14
CHEMBL3126458 IC50 = 226000.0 nM -
CHEMBL3126459 IC50 = 150000.0 nM -
CHEMBL3126473 IC50 = 124400.0 nM -