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Assay Detail

CHEMBL3132512

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CDK2 (unknown origin)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cyclin-dependent kinase 2 (CHEMBL301)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinases.
Johannes JW, Chuaqui C, Cowen S, Devereaux E, Gingipalli L, Molina A, Wang T, Whitston D, Wu X, Zhang HJ, Zinda M.
Bioorg Med Chem Lett (2014) 24 : 1138 -1143
PubMed 24462666 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.57 6.01

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3125732 1 6.01
CHEMBL3125721 1 5.84
CHEMBL2011936 1 5.55
CHEMBL3125722 1 4.87
CHEMBL3125720 1 -
CHEMBL3125723 1 -
CHEMBL3125724 1 -
CHEMBL3125725 1 -
CHEMBL3125726 1 -
CHEMBL3125728 1 -
CHEMBL373751 GSK-319347A 1 -
CHEMBL2011933 1 -
CHEMBL3125729 1 -
CHEMBL3125730 1 -
CHEMBL3125731 1 -
CHEMBL3125734 1 -
CHEMBL3125727 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3125732 IC50 = 984.0 nM 6.01
CHEMBL3125721 IC50 = 1450.0 nM 5.84
CHEMBL2011936 IC50 = 2790.0 nM 5.55
CHEMBL3125722 IC50 = 13600.0 nM 4.87
CHEMBL3125720 IC50 > 30000.0 nM -
CHEMBL3125723 IC50 > 30000.0 nM -
CHEMBL3125724 IC50 > 30000.0 nM -
CHEMBL3125725 IC50 > 30000.0 nM -
CHEMBL3125726 IC50 > 30000.0 nM -
CHEMBL3125728 IC50 > 30000.0 nM -
CHEMBL373751 GSK-319347A IC50 > 30000.0 nM -
CHEMBL2011933 IC50 > 4910.0 nM -
CHEMBL3125729 IC50 > 30000.0 nM -
CHEMBL3125730 IC50 > 30000.0 nM -
CHEMBL3125731 IC50 > 30000.0 nM -
CHEMBL3125734 IC50 > 30000.0 nM -
CHEMBL3125727 IC50 > 30000.0 nM -