Assay Detail
Binding
CHEMBL3134676
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Inhibition of recombinant human caspase-6 expressed in Escherichia coli using Ac-VEID-AMC as substrate preincubated for 30 mins before substrate addition measured after 2 hrs
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A new class of fluorinated 5-pyrrolidinylsulfonyl isatin caspase inhibitors for PET imaging of apoptosis
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.37 | 5.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3133258 | — | — | 1 | 5.42 |
| CHEMBL3133256 | — | — | 1 | 5.41 |
| CHEMBL3133146 | — | — | 1 | 5.29 |
| CHEMBL3133149 | — | — | 1 | - |
| CHEMBL3133148 | — | — | 1 | - |
| CHEMBL3133147 | — | — | 1 | - |
| CHEMBL3133259 | — | — | 1 | - |
| CHEMBL3133257 | — | — | 1 | - |
| CHEMBL3133255 | — | — | 1 | - |
| CHEMBL3133254 | — | — | 1 | - |
| CHEMBL3133253 | — | — | 1 | - |
| CHEMBL3133252 | — | — | 1 | - |
| CHEMBL3133251 | — | — | 1 | - |
| CHEMBL217777 | — | — | 1 | - |
| CHEMBL215480 | — | — | 1 | - |
| CHEMBL3133150 | — | — | 1 | - |
| CHEMBL213759 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3133258 | — | IC50 | = | 3790.0 | nM | 5.42 |
| CHEMBL3133256 | — | IC50 | = | 3878.0 | nM | 5.41 |
| CHEMBL3133146 | — | IC50 | = | 5082.0 | nM | 5.29 |
| CHEMBL3133149 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133147 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133259 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133257 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133255 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133253 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133252 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133251 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL217777 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL215480 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3133150 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL213759 | — | IC50 | > | 10000.0 | nM | - |