Assay Detail
Binding
CHEMBL3134684
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Time dependent inhibition of human recombinant MMP12 by SPR assay
5
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.98 | 9.28 |
| Ki(app) | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 9.28 |
| CHEMBL115727 | — | — | 1 | 9.21 |
| CHEMBL3133267 | — | — | 1 | 8.45 |
| CHEMBL3133269 | — | — | 1 | - |
| CHEMBL3133268 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19611 | ILOMASTAT | Ki | = | 0.52 | nM | 9.28 |
| CHEMBL115727 | — | Ki | = | 0.61 | nM | 9.21 |
| CHEMBL3133267 | — | Ki | = | 3.53 | nM | 8.45 |
| CHEMBL3133269 | — | Ki(app) | - | — | - | |
| CHEMBL3133268 | — | Ki(app) | - | — | - |