Assay Detail
Binding
CHEMBL3134686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant MMP12 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 10 mins prior to substrate addition by spectrophotometry
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.20 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3133269 | — | — | 1 | 9.00 |
| CHEMBL115727 | — | — | 1 | 8.72 |
| CHEMBL19611 | ILOMASTAT | 2.0 | 1 | 8.42 |
| CHEMBL3133267 | — | — | 1 | 7.52 |
| CHEMBL3133268 | — | — | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3133269 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL115727 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL19611 | ILOMASTAT | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL3133267 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL3133268 | — | Ki | = | 48.0 | nM | 7.32 |