Assay Detail
Binding
CHEMBL3134838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIM-1 (unknown origin) after 1 hr by HTRF assay
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase pim-1 (CHEMBL2147) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.24 | 5.89 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1398474 | — | — | 1 | 5.89 |
| CHEMBL3133837 | — | — | 1 | 5.17 |
| CHEMBL479 | THIORIDAZINE | 4.0 | 1 | 5.16 |
| CHEMBL1357558 | — | — | 1 | 5.15 |
| CHEMBL3133835 | — | — | 1 | 5.13 |
| CHEMBL3133836 | — | — | 1 | 5.09 |
| CHEMBL1688550 | — | — | 1 | 5.06 |
| CHEMBL908 | CHLORPROTHIXENE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1398474 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL3133837 | — | IC50 | = | 6730.0 | nM | 5.17 |
| CHEMBL479 | THIORIDAZINE | IC50 | = | 6890.0 | nM | 5.16 |
| CHEMBL1357558 | — | IC50 | = | 7030.0 | nM | 5.15 |
| CHEMBL3133835 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL3133836 | — | IC50 | = | 8160.0 | nM | 5.09 |
| CHEMBL1688550 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL908 | CHLORPROTHIXENE | Inhibition | - | % | - |