Assay Detail
Functional
CHEMBL3134893
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Induction of histone methylation in human MV4-11 cells assessed as H3K79 methylation after 4 days by Western blot analysis
5
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.70 | 6.70 |
| Activity | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3087502 | — | — | 2 | 6.70 |
| CHEMBL3087503 | — | — | 2 | 6.70 |
| CHEMBL2171169 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3087502 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3087503 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2171169 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3087502 | — | Activity | - | — | - | |
| CHEMBL3087503 | — | Activity | - | — | - |