Assay Detail
Binding
CHEMBL3134975
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Houston virus recombinant His6-tagged protease using EDANS-EPDFHLQGPEDLAK-Dabcyl as substrate preincubated for 45 mins followed by substrate addition measured every 1 min for 30 mins by FRET analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Houston virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis, Activity and Structure-Activity Relationship of Noroviral Protease Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.17 | 5.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134256 | — | — | 1 | 5.37 |
| CHEMBL3134254 | — | — | 1 | 5.34 |
| CHEMBL419332 | — | — | 1 | 5.12 |
| CHEMBL95007 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134256 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL3134254 | — | Ki | = | 4600.0 | nM | 5.34 |
| CHEMBL419332 | — | Ki | = | 7500.0 | nM | 5.12 |
| CHEMBL95007 | — | Ki | = | 14000.0 | nM | 4.85 |