Assay Detail
Binding
CHEMBL3135122
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Inhibition of human recombinant aromatase expressed in baculovirus infected insect cells using O-benzylfluorescein benzyl ester as substrate after 30 mins
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Flavans from Desmos cochinchinensis as potent aromatase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.82 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 8.96 |
| CHEMBL3134109 | — | — | 1 | 7.40 |
| CHEMBL3134113 | — | — | 1 | 7.10 |
| CHEMBL3134112 | — | — | 1 | 7.05 |
| CHEMBL3134114 | — | — | 1 | 6.82 |
| CHEMBL3134115 | — | — | 1 | 6.22 |
| CHEMBL3134110 | — | — | 1 | 6.00 |
| CHEMBL3134111 | — | — | 1 | 4.97 |
| CHEMBL53343 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1444 | LETROZOLE | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL3134109 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3134113 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3134112 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3134114 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3134115 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3134110 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL3134111 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL53343 | — | IC50 | > | 12500.0 | nM | - |