Assay Detail
Binding
CHEMBL3135672
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Inhibition of Mycobacterium tuberculosis ADK using [3H]-adenosine by scintillation counting method
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Adenosine kinase (CHEMBL4105883) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) |
Publication
6-Alkyl-, 6-aryl- or 6-hetaryl-7-deazapurine ribonucleosides as inhibitors of human or MTB adenosine kinase and potential antimycobacterial agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 6.76 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3134389 | — | — | 1 | 8.12 |
| CHEMBL3134388 | — | — | 1 | 7.84 |
| CHEMBL572327 | — | — | 1 | 7.64 |
| CHEMBL571756 | — | — | 1 | 7.55 |
| CHEMBL576130 | — | — | 1 | 7.52 |
| CHEMBL569854 | — | — | 1 | 7.46 |
| CHEMBL3134378 | — | — | 1 | 7.40 |
| CHEMBL585761 | — | — | 1 | 7.34 |
| CHEMBL572326 | — | — | 1 | 7.24 |
| CHEMBL572317 | — | — | 1 | 7.23 |
| CHEMBL571757 | — | — | 1 | 7.20 |
| CHEMBL584957 | — | — | 1 | 7.16 |
| CHEMBL584958 | — | — | 1 | 7.16 |
| CHEMBL571978 | — | — | 1 | 7.14 |
| CHEMBL572052 | — | — | 1 | 7.10 |
| CHEMBL585759 | — | — | 1 | 6.96 |
| CHEMBL585760 | — | — | 1 | 6.92 |
| CHEMBL571838 | — | — | 1 | 6.92 |
| CHEMBL3134379 | — | — | 1 | 6.82 |
| CHEMBL571631 | — | — | 1 | 6.82 |
| CHEMBL571622 | — | — | 1 | 6.72 |
| CHEMBL572100 | — | — | 1 | 6.71 |
| CHEMBL584541 | — | — | 1 | 6.70 |
| CHEMBL570743 | — | — | 1 | 6.66 |
| CHEMBL570092 | — | — | 1 | 6.60 |
| CHEMBL576900 | — | — | 1 | 6.52 |
| CHEMBL571848 | — | — | 1 | 6.52 |
| CHEMBL572309 | — | — | 1 | 6.50 |
| CHEMBL571410 | — | — | 1 | 6.50 |
| CHEMBL570091 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3134389 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3134388 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL572327 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL571756 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL576130 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL569854 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3134378 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL585761 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL572326 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL572317 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL571757 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL584957 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL584958 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL571978 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL572052 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL585759 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL585760 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL571838 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3134379 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL571631 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL571622 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL572100 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL584541 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL570743 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL570092 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL576900 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL571848 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL572309 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL571410 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL570091 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL3134381 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL576702 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL571850 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL571630 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL576515 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3134380 | — | IC50 | = | 1460.0 | nM | 5.84 |
| CHEMBL1642653 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL578623 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL1269812 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL576514 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL571406 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3134382 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3134383 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3134384 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3134385 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3134386 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3134387 | — | IC50 | > | 20000.0 | nM | - |