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Assay Detail

CHEMBL3135827

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human K562 cells assessed as growth inhibition
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type K562
Confidence 1 — Organism
Curated By Autocuration

Target

K562 (CHEMBL385)
Type CELL-LINE
Organism Homo sapiens

Publication

Novel benzofuranchromone and coumarin derivatives: synthesis and biological activity in K562 human leukemia cells
Zwergel C, Valente S, Salvato A, Xu Z, Talhi O, Mai A, Silva A, Altucci L, Kirsch G
Medchemcomm (2013) 4 : 1571 -1579
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 4.35 4.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL123092 1 4.40
CHEMBL126094 1 4.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL123092 IC50 = 40000.0 nM 4.40
CHEMBL126094 IC50 = 50000.0 nM 4.30