Assay Detail
Binding
CHEMBL3136005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DGAT1 in rat liver microsomes
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Diacylglycerol O-acyltransferase 1 (CHEMBL6129) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Optimisation of biphenyl acetic acid inhibitors of diacylglycerol acetyl transferase 1 the discovery of AZD2353
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3133093 | — | — | 1 | 8.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3133093 | — | IC50 | = | 3.981 | nM | 8.40 |