Assay Detail
Binding
CHEMBL3136322
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged Mycobacterium tuberculosis DXR expressed in Escherichia coli BL21(DE3) using DXP as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by NADPH and substrate addition by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.15 | 6.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | 3.0 | 1 | 6.51 |
| CHEMBL1922604 | — | — | 1 | 5.62 |
| CHEMBL3133710 | — | — | 1 | 4.75 |
| CHEMBL3133709 | — | — | 1 | 4.57 |
| CHEMBL3133715 | — | — | 1 | 4.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL203125 | FOSMIDOMYCIN | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1922604 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL3133710 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL3133709 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL3133715 | — | IC50 | = | 48400.0 | nM | 4.32 |