Assay Detail
Binding
CHEMBL3136337
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGFR2 (unknown origin) after 1 hr by Caliper mobility shift assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and discovery of 4-anilinoquinazoline ureas as multikinase inhibitors targeting BRAF, VEGFR-2 and EGFR
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.71 | 7.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3133751 | — | — | 1 | 7.77 |
| CHEMBL1336 | SORAFENIB | 4.0 | 1 | 7.28 |
| CHEMBL3133756 | — | — | 1 | 7.12 |
| CHEMBL3133757 | — | — | 1 | 7.04 |
| CHEMBL3133758 | — | — | 1 | 7.02 |
| CHEMBL3133752 | — | — | 1 | 6.67 |
| CHEMBL3133755 | — | — | 1 | 5.67 |
| CHEMBL3133754 | — | — | 1 | 5.07 |
| CHEMBL3133753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3133751 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3133756 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3133757 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL3133758 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL3133752 | — | IC50 | = | 213.0 | nM | 6.67 |
| CHEMBL3133755 | — | IC50 | = | 2165.0 | nM | 5.67 |
| CHEMBL3133754 | — | IC50 | = | 8568.0 | nM | 5.07 |
| CHEMBL3133753 | — | IC50 | > | 10000.0 | nM | - |