Assay Detail
Binding
CHEMBL3136602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]histamine from human histamine H4 receptor E182'5.46Q mutant transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mapping histamine H4receptorligand binding modes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.03 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | — | 1 | 7.50 |
| CHEMBL492884 | — | — | 1 | 7.20 |
| CHEMBL493720 | — | — | 1 | 6.70 |
| CHEMBL129199 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129198 | JNJ-7777120 | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL492884 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL493720 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL129199 | — | Ki | = | 199.53 | nM | 6.70 |