Assay Detail
Binding
CHEMBL3136604
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Displacement of [3H]histamine from wild type human histamine H4 receptor transfected in HEK293T cells after 1.5 hrs by liquid scintillation counting analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK-293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Mapping histamine H4receptorligand binding modes
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.59 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493720 | — | — | 1 | 8.70 |
| CHEMBL3133130 | — | — | 1 | 8.30 |
| CHEMBL492884 | — | — | 1 | 8.30 |
| CHEMBL3133131 | — | — | 1 | 8.10 |
| CHEMBL494648 | — | — | 1 | 7.80 |
| CHEMBL129198 | JNJ-7777120 | — | 1 | 7.70 |
| CHEMBL340740 | — | — | 1 | 7.60 |
| CHEMBL129199 | — | — | 1 | 7.10 |
| CHEMBL2047270 | — | — | 1 | 7.00 |
| CHEMBL128637 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493720 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL3133130 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL492884 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL3133131 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL494648 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL129198 | JNJ-7777120 | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL340740 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL129199 | — | Ki | = | 79.43 | nM | 7.10 |
| CHEMBL2047270 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL128637 | — | Ki | = | 5011.87 | nM | 5.30 |