Assay Detail
Binding
CHEMBL3136959
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]spiperone from human recombinant dopamine D2L receptor expressed in CHOFlpIn cells after 3 hrs by liquid scintillation counting
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.80 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.93 |
| CHEMBL3134068 | — | — | 1 | 6.74 |
| CHEMBL3134067 | — | — | 1 | 5.87 |
| CHEMBL3134071 | — | — | 1 | 5.81 |
| CHEMBL3134070 | — | — | 1 | 5.57 |
| CHEMBL3134066 | — | — | 1 | 5.44 |
| CHEMBL3134064 | — | — | 1 | 5.36 |
| CHEMBL3134065 | — | — | 1 | 5.27 |
| CHEMBL3134063 | — | — | 1 | 5.18 |
| CHEMBL3134069 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53 | APOMORPHINE | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL3134068 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL3134067 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL3134071 | — | IC50 | = | 1550.0 | nM | 5.81 |
| CHEMBL3134070 | — | IC50 | = | 2680.0 | nM | 5.57 |
| CHEMBL3134066 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3134064 | — | IC50 | = | 4360.0 | nM | 5.36 |
| CHEMBL3134065 | — | IC50 | = | 5320.0 | nM | 5.27 |
| CHEMBL3134063 | — | IC50 | = | 6540.0 | nM | 5.18 |
| CHEMBL3134069 | — | IC50 | - | — | - |