Assay Detail
Binding
CHEMBL3222370
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human catalytic domain of TACE assessed as inhibit the cleavage of the substrate by fluorescence-based FRET assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 17 (CHEMBL3706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis and biological evaluation of -lactam hydroxamate based TACE inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.41 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3221863 | — | — | 1 | 8.68 |
| CHEMBL3221864 | — | — | 1 | 8.64 |
| CHEMBL489100 | — | — | 1 | 7.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3221863 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3221864 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL489100 | — | IC50 | = | 12.0 | nM | 7.92 |