Assay Detail
Binding
CHEMBL3222704
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Inhibition of N-terminal truncated Plasmodium falciparum recombinant DHODH assessed as ubiquinone reduction to 2,6-dichloroindophenol by spectrophotometric analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dihydroorotate dehydrogenase (CHEMBL3486) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
N-Substituted salicylamides as selective malaria parasite dihydroorotate dehydrogenase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.82 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218518 | — | — | 1 | 5.16 |
| CHEMBL3218529 | — | — | 1 | 5.10 |
| CHEMBL3218517 | — | — | 1 | 5.04 |
| CHEMBL3218520 | — | — | 1 | 5.00 |
| CHEMBL3218516 | — | — | 1 | 4.99 |
| CHEMBL3218519 | — | — | 1 | 4.97 |
| CHEMBL3218524 | — | — | 1 | 4.85 |
| CHEMBL3218522 | — | — | 1 | 4.84 |
| CHEMBL3218530 | — | — | 1 | 4.78 |
| CHEMBL3218525 | — | — | 1 | 4.74 |
| CHEMBL3218512 | — | — | 1 | 4.67 |
| CHEMBL3217764 | — | — | 1 | 4.58 |
| CHEMBL3218515 | — | — | 1 | 4.36 |
| CHEMBL3218528 | — | — | 1 | 4.33 |
| CHEMBL3218521 | — | — | 1 | - |
| CHEMBL3218523 | — | — | 1 | - |
| CHEMBL3218526 | — | — | 1 | - |
| CHEMBL3218527 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218518 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3218529 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL3218517 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL3218520 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL3218516 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3218519 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL3218524 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL3218522 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL3218530 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL3218525 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL3218512 | — | IC50 | = | 21200.0 | nM | 4.67 |
| CHEMBL3217764 | — | IC50 | = | 26100.0 | nM | 4.58 |
| CHEMBL3218515 | — | IC50 | = | 44100.0 | nM | 4.36 |
| CHEMBL3218528 | — | IC50 | = | 46200.0 | nM | 4.33 |
| CHEMBL3218521 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL3218523 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL3218526 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL3218527 | — | IC50 | > | 100000.0 | nM | - |