Assay Detail
Binding
CHEMBL3222770
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant DGAT1 expressed in baculovirus infected insect sf9 cells using [14C] oleoyl coenzyme A after 30 mins by scintillation counting
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 34 | 7.50 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3222247 | — | — | 1 | 8.30 |
| CHEMBL3133098 | — | — | 1 | 8.20 |
| CHEMBL3222262 | — | — | 1 | 8.11 |
| CHEMBL3222257 | — | — | 1 | 8.00 |
| CHEMBL3222250 | — | — | 1 | 8.00 |
| CHEMBL3222245 | — | — | 1 | 7.80 |
| CHEMBL3222259 | — | — | 1 | 7.80 |
| CHEMBL3222256 | — | — | 1 | 7.80 |
| CHEMBL3222253 | — | — | 1 | 7.80 |
| CHEMBL3222258 | — | — | 1 | 7.70 |
| CHEMBL3222232 | — | — | 1 | 7.70 |
| CHEMBL3222249 | — | — | 1 | 7.70 |
| CHEMBL3222230 | — | — | 1 | 7.60 |
| CHEMBL3222248 | — | — | 1 | 7.60 |
| CHEMBL3222231 | — | — | 1 | 7.50 |
| CHEMBL3222239 | — | — | 1 | 7.50 |
| CHEMBL3222238 | — | — | 1 | 7.50 |
| CHEMBL3222261 | — | — | 1 | 7.50 |
| CHEMBL3222235 | — | — | 1 | 7.40 |
| CHEMBL3222242 | — | — | 1 | 7.40 |
| CHEMBL3222255 | — | — | 1 | 7.40 |
| CHEMBL3222233 | — | — | 1 | 7.40 |
| CHEMBL3222237 | — | — | 1 | 7.30 |
| CHEMBL3222244 | — | — | 1 | 7.30 |
| CHEMBL3222234 | — | — | 1 | 7.30 |
| CHEMBL3222243 | — | — | 1 | 7.30 |
| CHEMBL3222246 | — | — | 1 | 7.30 |
| CHEMBL3222236 | — | — | 1 | 7.30 |
| CHEMBL3222241 | — | — | 1 | 7.20 |
| CHEMBL3222251 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3222247 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL3133098 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL3222262 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3222257 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3222250 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3222245 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3222259 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3222256 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3222253 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL3222258 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3222232 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3222249 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL3222230 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3222248 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL3222239 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3222238 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3222261 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3222231 | — | IC50 | = | 31.62 | nM | 7.50 |
| CHEMBL3222235 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3222242 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3222255 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3222233 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL3222243 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3222236 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3222246 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3222234 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3222244 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3222237 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL3222241 | — | IC50 | = | 63.1 | nM | 7.20 |
| CHEMBL3222251 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3222240 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3222260 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL3222254 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL3222252 | — | IC50 | = | 316.23 | nM | 6.50 |