Assay Detail
Binding
CHEMBL3222889
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Antagonist activity at adenosine A2B receptor (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR mining and its application to the design of TRPA1 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.19 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334325 | — | — | 1 | 7.30 |
| CHEMBL121766 | — | — | 1 | 6.90 |
| CHEMBL339936 | — | — | 1 | 6.60 |
| CHEMBL421256 | — | — | 1 | 6.19 |
| CHEMBL127876 | — | — | 1 | 5.68 |
| CHEMBL124485 | — | — | 1 | 5.44 |
| CHEMBL125670 | — | — | 1 | 5.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334325 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL121766 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL339936 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL421256 | — | IC50 | = | 645.0 | nM | 6.19 |
| CHEMBL127876 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL124485 | — | IC50 | = | 3660.0 | nM | 5.44 |
| CHEMBL125670 | — | IC50 | = | 5830.0 | nM | 5.23 |