Assay Detail
Binding
CHEMBL3222890
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Antagonist activity at 5TH4 receptor (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SAR mining and its application to the design of TRPA1 antagonists
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.44 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220223 | — | — | 1 | 8.85 |
| CHEMBL334325 | — | — | 1 | 8.52 |
| CHEMBL421256 | — | — | 1 | 7.77 |
| CHEMBL339936 | — | — | 1 | 7.75 |
| CHEMBL121766 | — | — | 1 | 7.19 |
| CHEMBL127876 | — | — | 1 | 6.79 |
| CHEMBL125670 | — | — | 1 | 6.53 |
| CHEMBL124485 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220223 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL334325 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL421256 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL339936 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL121766 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL127876 | — | IC50 | = | 162.0 | nM | 6.79 |
| CHEMBL125670 | — | IC50 | = | 296.0 | nM | 6.53 |
| CHEMBL124485 | — | IC50 | = | 715.0 | nM | 6.15 |