Assay Detail
Binding
CHEMBL3222928
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGF-BB-induced Rac activation in human SMC assessed as intracellular Rac-GTP level incubated for 4 hrs prior to PDGF-BB stimulation for 2 mins by G-LISA
7
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
3-Aryl-N-aminoylsulfonylphenyl-1H-pyrazole-5-carboxamides: a new class of selective Rac inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.89 | 5.36 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218628 | — | — | 2 | 5.36 |
| CHEMBL579882 | — | — | 2 | 5.06 |
| CHEMBL548644 | — | — | 1 | 4.79 |
| CHEMBL587943 | — | — | 1 | 4.72 |
| CHEMBL3218627 | — | — | 1 | 4.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218628 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL579882 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL548644 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL587943 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL3218627 | — | IC50 | = | 29100.0 | nM | 4.54 |
| CHEMBL3218628 | — | Inhibition | - | % | - | |
| CHEMBL579882 | — | Inhibition | - | % | - |