Assay Detail
Functional
CHEMBL3223055
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Antimalarial activity against Plasmodium falciparum W2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of novel benzothiazole and triazole analogs as falcipain inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.54 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 7.92 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.21 |
| CHEMBL3218751 | — | — | 1 | 5.68 |
| CHEMBL3218764 | — | — | 1 | 5.33 |
| CHEMBL3218778 | — | — | 1 | - |
| CHEMBL3218779 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269671 | ARTEMISININ | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL3218751 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL3218764 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL3218778 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3218779 | — | IC50 | > | 10000.0 | nM | - |