Assay Detail

CHEMBL3223357

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of p53 interaction to MDM2 (unknown origin) by surface plasmon resonance assay

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Tumour suppressor p53/oncoprotein Mdm2

CHEMBL1907611

Anchored from Assay target.

Protein identity Tumour suppressor p53/oncoprotein Mdm2

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	5 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Tumour suppressor p53/oncoprotein Mdm2 (CHEMBL1907611) ↗

Type	PROTEIN-PROTEIN INTERACTION
Organism	Homo sapiens

Publication

The p53-MDM2/MDMX axis - A chemotype perspective.

Khoury K, Popowicz GM, Holak TA, Dömling A.
Medchemcomm (2011) 2 : 246 -260
PubMed 24466404 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.85	6.85

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL407632	NUTLIN-2	—	1	6.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL407632	NUTLIN-2	IC50	=	140.0	nM	6.85