Assay Detail
Binding
CHEMBL3223500
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Inhibition of HIF-1 (unknown origin) expressed in human HeLa cells after 12 hrs by HRE luciferase reporter gene assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.06 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220252 | — | — | 1 | 7.16 |
| CHEMBL434085 | — | — | 1 | 7.00 |
| CHEMBL3220253 | — | — | 1 | 6.75 |
| CHEMBL164712 | — | — | 1 | 6.58 |
| CHEMBL3220249 | — | — | 1 | 6.57 |
| CHEMBL164448 | — | — | 1 | 6.52 |
| CHEMBL3220251 | — | — | 1 | 6.51 |
| CHEMBL164379 | — | — | 1 | 6.34 |
| CHEMBL353853 | — | — | 1 | 6.32 |
| CHEMBL350349 | — | — | 1 | 6.28 |
| CHEMBL3220258 | — | — | 1 | 6.21 |
| CHEMBL3220254 | — | — | 1 | 6.19 |
| CHEMBL3220257 | — | — | 1 | 6.16 |
| CHEMBL3220256 | — | — | 1 | 6.08 |
| CHEMBL3220250 | — | — | 1 | 6.01 |
| CHEMBL202258 | — | — | 1 | 5.91 |
| CHEMBL333985 | — | — | 1 | 5.70 |
| CHEMBL3220255 | — | — | 1 | 5.55 |
| CHEMBL3220246 | — | — | 1 | 5.48 |
| CHEMBL3220259 | — | — | 1 | 5.16 |
| CHEMBL3220245 | — | — | 1 | 5.05 |
| CHEMBL3220248 | — | — | 1 | 5.03 |
| CHEMBL3220247 | — | — | 1 | 4.86 |
| CHEMBL3220260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220252 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL434085 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3220253 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL164712 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3220249 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL164448 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3220251 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL164379 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL353853 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL350349 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL3220258 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL3220254 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3220257 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3220256 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL3220250 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL202258 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL333985 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3220255 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL3220246 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL3220259 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL3220245 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL3220248 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL3220247 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL3220260 | — | IC50 | > | 30000.0 | nM | - |