Assay Detail
Binding
CHEMBL3223609
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Inhibition of PI3Kdelta (unknown origin)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules targeting phosphoinositide 3-kinases
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.71 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | 4.0 | 1 | 8.60 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 8.52 |
| CHEMBL1233881 | — | — | 1 | 8.40 |
| CHEMBL586702 | ZSTK-474 | 2.0 | 1 | 8.30 |
| CHEMBL1233882 | — | — | 1 | 8.22 |
| CHEMBL1922094 | APITOLISIB | 2.0 | 1 | 8.15 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.15 |
| CHEMBL3218575 | — | — | 1 | 7.44 |
| CHEMBL3349370 | — | — | 1 | 7.37 |
| CHEMBL1241857 | — | — | 1 | 7.24 |
| CHEMBL1229535 | — | — | 1 | 6.92 |
| CHEMBL1081312 | — | — | 1 | 6.82 |
| CHEMBL1230790 | — | — | 1 | 6.60 |
| CHEMBL2064328 | — | — | 1 | 6.58 |
| CHEMBL3218571 | — | — | 1 | 6.47 |
| CHEMBL1684984 | IZORLISIB | 2.0 | 1 | 6.30 |
| CHEMBL1213082 | — | — | 1 | 6.30 |
| CHEMBL3218572 | — | — | 1 | 6.20 |
| CHEMBL1234815 | — | — | 1 | 6.10 |
| CHEMBL3218574 | — | — | 1 | 6.06 |
| CHEMBL3218573 | — | — | 1 | 6.00 |
| CHEMBL3218580 | — | — | 1 | 5.49 |
| CHEMBL2181110 | — | — | 1 | 5.29 |
| CHEMBL478980 | — | — | 1 | 4.66 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.12 |
| CHEMBL1355736 | THEOPHYLLINE | 4.0 | 1 | 4.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2216870 | IDELALISIB | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1233881 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL586702 | ZSTK-474 | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1233882 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1922094 | APITOLISIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3218575 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3349370 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL1241857 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL1229535 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1081312 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1230790 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2064328 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL3218571 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL1684984 | IZORLISIB | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1213082 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3218572 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1234815 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3218574 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL3218573 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL3218580 | — | IC50 | = | 3225.0 | nM | 5.49 |
| CHEMBL2181110 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL478980 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL113 | CAFFEINE | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL1355736 | THEOPHYLLINE | IC50 | = | 75000.0 | nM | 4.12 |