Assay Detail
Binding
CHEMBL3223676
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Inhibition of recombinant human pancreatic glucokinase by G-6-P dehydrogenase assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Property based optimisation of glucokinase activators discovery of the phase IIb clinical candidate AZD1656
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 7.22 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3217925 | — | — | 1 | 7.52 |
| CHEMBL3219105 | — | — | 1 | 7.51 |
| CHEMBL3219108 | — | — | 1 | 7.50 |
| CHEMBL3219109 | — | — | 1 | 7.46 |
| CHEMBL3219121 | — | — | 1 | 7.44 |
| CHEMBL3219115 | — | — | 1 | 7.43 |
| CHEMBL3219119 | — | — | 1 | 7.33 |
| CHEMBL3219107 | — | — | 1 | 7.28 |
| CHEMBL3219123 | — | — | 1 | 7.22 |
| CHEMBL3219124 | AZD-1656 | 2.0 | 1 | 7.21 |
| CHEMBL3219110 | — | — | 1 | 7.21 |
| CHEMBL3219117 | — | — | 1 | 7.16 |
| CHEMBL3219120 | — | — | 1 | 7.14 |
| CHEMBL3219106 | — | — | 1 | 7.14 |
| CHEMBL3219116 | — | — | 1 | 6.96 |
| CHEMBL3219118 | — | — | 1 | 6.77 |
| CHEMBL3219122 | — | — | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3217925 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3219105 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3219108 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3219109 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL3219121 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL3219115 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL3219119 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3219107 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL3219123 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3219124 | AZD-1656 | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3219110 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL3219117 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3219120 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3219106 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3219116 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3219118 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3219122 | — | EC50 | = | 370.0 | nM | 6.43 |