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Assay Detail

CHEMBL3223784

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against wild type Plasmodium falciparum 3D7 assessed as growth inhibition
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

The development of quinoloneesters as novel antimalarial agents targeting the Plasmodium falciparum bc1protein complex
Cowley R, Leung S, Fisher N, Al-Helal M, Berry NG, Lawrenson AS, Sharma R, Shone AE, Ward SA, Biagini GA, ONeill PM
Medchemcomm (2012) 3 : 39 -44
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 7.03 9.34

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3219636 1 9.34
CHEMBL3219630 1 8.34
CHEMBL3219638 1 8.30
CHEMBL3219634 1 8.28
CHEMBL3219644 1 8.07
CHEMBL3219629 1 7.71
CHEMBL3219646 1 7.53
CHEMBL381059 1 7.39
CHEMBL3219635 1 6.85
CHEMBL3219628 1 6.79
CHEMBL3219643 1 6.74
CHEMBL3219633 1 6.64
CHEMBL3219637 1 6.17
CHEMBL3219645 1 5.74
CHEMBL3219641 1 5.33
CHEMBL3219642 1 5.17
CHEMBL3219640 1 5.09
CHEMBL3219632 1 -
CHEMBL3219631 1 -
CHEMBL3219639 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3219636 IC50 = 0.46 nM 9.34
CHEMBL3219630 IC50 = 4.57 nM 8.34
CHEMBL3219638 IC50 = 5.0 nM 8.30
CHEMBL3219634 IC50 = 5.3 nM 8.28
CHEMBL3219644 IC50 = 8.45 nM 8.07
CHEMBL3219629 IC50 = 19.3 nM 7.71
CHEMBL3219646 IC50 = 29.6 nM 7.53
CHEMBL381059 IC50 = 40.4 nM 7.39
CHEMBL3219635 IC50 = 141.5 nM 6.85
CHEMBL3219628 IC50 = 164.0 nM 6.79
CHEMBL3219643 IC50 = 183.9 nM 6.74
CHEMBL3219633 IC50 = 229.8 nM 6.64
CHEMBL3219637 IC50 = 674.8 nM 6.17
CHEMBL3219645 IC50 = 1820.4 nM 5.74
CHEMBL3219641 IC50 = 4698.0 nM 5.33
CHEMBL3219642 IC50 = 6725.0 nM 5.17
CHEMBL3219640 IC50 = 8102.5 nM 5.09
CHEMBL3219632 IC50 - -
CHEMBL3219631 IC50 - -
CHEMBL3219639 IC50 > 10000.0 nM -