Assay Detail
Functional
CHEMBL3224136
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Antiviral activity against Influenza B virus (B/Harbin/07/94) infected in MDCK cells assessed as reduction of virus-induced cytopathic effect after 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza B virus |
| Cell Type | MDCK |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.66 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218394 | — | — | 1 | 9.49 |
| CHEMBL3218395 | — | — | 1 | 9.41 |
| CHEMBL3218399 | — | — | 1 | 9.37 |
| CHEMBL3218398 | — | — | 1 | 9.29 |
| CHEMBL3218396 | — | — | 1 | 9.19 |
| CHEMBL3218400 | — | — | 1 | 9.10 |
| CHEMBL3218397 | — | — | 1 | 9.06 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 6.83 |
| CHEMBL1229 | OSELTAMIVIR | 4.0 | 1 | 6.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218394 | — | EC50 | = | 0.32 | nM | 9.49 |
| CHEMBL3218395 | — | EC50 | = | 0.39 | nM | 9.41 |
| CHEMBL3218399 | — | EC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3218398 | — | EC50 | = | 0.51 | nM | 9.29 |
| CHEMBL3218396 | — | EC50 | = | 0.65 | nM | 9.19 |
| CHEMBL3218400 | — | EC50 | = | 0.79 | nM | 9.10 |
| CHEMBL3218397 | — | EC50 | = | 0.88 | nM | 9.06 |
| CHEMBL222813 | ZANAMIVIR | EC50 | = | 149.0 | nM | 6.83 |
| CHEMBL1229 | OSELTAMIVIR | EC50 | = | 583.0 | nM | 6.23 |