Assay Detail
Functional
CHEMBL3224249
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Antiproliferative activity against human K562 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Amino-derivatives of the sesquiterpene lactone class of natural products as prodrugs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.99 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL136356 | HELENINE | — | 1 | 6.16 |
| CHEMBL344918 | — | — | 1 | 6.16 |
| CHEMBL137803 | ISOALANTOLACTONE | — | 1 | 5.92 |
| CHEMBL137440 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL136356 | HELENINE | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL344918 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL137803 | ISOALANTOLACTONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL137440 | — | IC50 | = | 2000.0 | nM | 5.70 |