Assay Detail
Functional
CHEMBL3224345
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Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antimalarial peroxides: advances in drug discovery and design
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.77 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2387268 | — | — | 1 | 8.72 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.55 |
| CHEMBL3221650 | — | — | 1 | 7.64 |
| CHEMBL3221649 | — | — | 1 | 7.54 |
| CHEMBL3221652 | — | — | 1 | 7.25 |
| CHEMBL3221651 | — | — | 1 | 6.94 |
| CHEMBL100896 | — | — | 1 | - |
| CHEMBL3221656 | — | — | 1 | - |
| CHEMBL3221655 | — | — | 1 | - |
| CHEMBL3221654 | — | — | 1 | - |
| CHEMBL3221653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2387268 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL3221650 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3221649 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL3221652 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3221651 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL100896 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL3221656 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL3221655 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL3221654 | — | IC50 | < | 5.0 | nM | - |
| CHEMBL3221653 | — | IC50 | < | 5.0 | nM | - |