Assay Detail

CHEMBL3224371

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Binding

Inhibition of purified calf kidney ALR1 preincubated for 10 mins by UV spectrophotometry

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Bos taurus
Tissue	Kidney
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Design, synthesis and molecular modelling of novel methyl[4-oxo-2-(aroylimino)-3-(substituted phenyl)thiazolidin-5-ylidene]acetates as potent and selective aldose reductase inhibitors

Ali S, Saeed A, Abbas N, Shahid M, Bolte M, Iqbal J
Medchemcomm (2012) 3 : 1428 -1434
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	4.24	4.24

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL109	VALPROIC ACID	4.0	1	4.24

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL109	VALPROIC ACID	IC50	=	57400.0	nM	4.24