Assay Detail
Binding
CHEMBL3224666
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Inhibition of DNA polymerase alpha (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of an HIV integrase inhibitor with an excellent resistance profile
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.14 | 5.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29711 | APHIDICOLIN | — | 1 | 5.14 |
| CHEMBL566812 | — | — | 1 | 5.14 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | -1.0 | 1 | 5.14 |
| CHEMBL3219143 | PF-04776548 | 1.0 | 1 | - |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29711 | APHIDICOLIN | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL566812 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL193952 | ZIDOVUDINE TRIPHOSPHATE | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL3219143 | PF-04776548 | IC50 | > | 100000.0 | nM | - |
| CHEMBL223228 | EFAVIRENZ | IC50 | > | 50000.0 | nM | - |