Assay Detail
Functional
CHEMBL3225044
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Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 48 hrs by betaplate liquid scintillation counting analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Second generation analogues of RKA182: synthetic tetraoxanes with outstanding in vitro and in vivo antimalarial activities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.91 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3218240 | — | — | 1 | 9.70 |
| CHEMBL3218241 | — | — | 1 | 9.70 |
| CHEMBL3218235 | — | — | 1 | 9.40 |
| CHEMBL3218232 | — | — | 1 | 9.40 |
| CHEMBL3218238 | — | — | 1 | 9.40 |
| CHEMBL3218234 | — | — | 1 | 9.05 |
| CHEMBL3218233 | — | — | 1 | 9.00 |
| CHEMBL3218236 | — | — | 1 | 8.96 |
| CHEMBL2387268 | — | — | 1 | 8.95 |
| CHEMBL3218242 | — | — | 1 | 8.92 |
| CHEMBL3218239 | — | — | 1 | 8.89 |
| CHEMBL3218237 | — | — | 1 | 8.60 |
| CHEMBL361497 | ARTESUNATE | 4.0 | 1 | 8.31 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.49 |
| CHEMBL3218243 | — | — | 1 | - |
| CHEMBL3218244 | — | — | 1 | - |
| CHEMBL3218245 | — | — | 1 | - |
| CHEMBL3218246 | — | — | 1 | - |
| CHEMBL3218247 | — | — | 1 | - |
| CHEMBL3218248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3218240 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3218241 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3218235 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3218232 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3218238 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL3218234 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL3218233 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL3218236 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL2387268 | — | IC50 | = | 1.119 | nM | 8.95 |
| CHEMBL3218242 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3218239 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3218237 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL361497 | ARTESUNATE | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 325.0 | nM | 6.49 |
| CHEMBL3218243 | — | IC50 | - | — | - | |
| CHEMBL3218244 | — | IC50 | - | — | - | |
| CHEMBL3218245 | — | IC50 | - | — | - | |
| CHEMBL3218246 | — | IC50 | - | — | - | |
| CHEMBL3218247 | — | IC50 | - | — | - | |
| CHEMBL3218248 | — | IC50 | - | — | - |