Assay Detail
Binding
CHEMBL3225083
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP11B2 (unknown origin) expressed in Chinese hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate preincubated for 60 mins followed by substrate addition measured after 50 mins by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZ |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.14 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL934 | METYRAPONE | 4.0 | 1 | 7.14 |
| CHEMBL3219070 | — | — | 1 | - |
| CHEMBL3219071 | — | — | 1 | - |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL934 | METYRAPONE | IC50 | = | 71.8 | nM | 7.14 |
| CHEMBL3219070 | — | IC50 | - | — | - | |
| CHEMBL3219071 | — | IC50 | - | — | - | |
| CHEMBL1444 | LETROZOLE | IC50 | - | — | - |