Assay Detail
Binding
CHEMBL3225086
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Inhibition of CYP19 isolated from microsomal fraction of human term placental tissue using [1beta-3H] androstenedione as substrate preincubated for 5 mins followed by enzyme addition measured after 20 mins by beta scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of imidazolylmethylacridones as cytochrome P-450 enzymes inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.64 | 7.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219070 | — | — | 1 | 7.84 |
| CHEMBL1444 | LETROZOLE | 4.0 | 1 | 7.44 |
| CHEMBL3219071 | — | — | 1 | - |
| CHEMBL934 | METYRAPONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219070 | — | IC50 | = | 14.4 | nM | 7.84 |
| CHEMBL1444 | LETROZOLE | IC50 | = | 36.2 | nM | 7.44 |
| CHEMBL3219071 | — | IC50 | - | — | - | |
| CHEMBL934 | METYRAPONE | IC50 | - | — | - |