Assay Detail
Binding
CHEMBL3225185
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Activation of recombinant human His6-tagged glucokinase by G6PDH-coupled spectrophotometry
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-(5-substituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl) propanamides as glucokinase activators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.35 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL499520 | — | — | 1 | 7.21 |
| CHEMBL1164184 | — | — | 1 | 7.05 |
| CHEMBL1164578 | — | — | 1 | 6.80 |
| CHEMBL3218723 | — | — | 1 | 6.77 |
| CHEMBL3218731 | — | — | 1 | 6.75 |
| CHEMBL3218727 | — | — | 1 | 6.68 |
| CHEMBL3218732 | — | — | 1 | 6.66 |
| CHEMBL3218730 | — | — | 1 | 6.54 |
| CHEMBL3218726 | — | — | 1 | 6.52 |
| CHEMBL3218722 | — | — | 1 | 6.48 |
| CHEMBL3218720 | — | — | 1 | 6.46 |
| CHEMBL3218719 | — | — | 1 | 6.35 |
| CHEMBL3218714 | — | — | 1 | 6.28 |
| CHEMBL3218729 | — | — | 1 | 6.19 |
| CHEMBL3218728 | — | — | 1 | 6.10 |
| CHEMBL3218721 | — | — | 1 | 5.87 |
| CHEMBL3218716 | — | — | 1 | 5.84 |
| CHEMBL3217766 | — | — | 1 | 5.82 |
| CHEMBL3218715 | — | — | 1 | 5.75 |
| CHEMBL3218717 | — | — | 1 | 4.95 |
| CHEMBL3218718 | — | — | 1 | - |
| CHEMBL3218724 | — | — | 1 | - |
| CHEMBL3218725 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL499520 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL1164184 | — | EC50 | = | 89.0 | nM | 7.05 |
| CHEMBL1164578 | — | EC50 | = | 157.0 | nM | 6.80 |
| CHEMBL3218723 | — | EC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3218731 | — | EC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3218727 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL3218732 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3218730 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL3218726 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3218722 | — | EC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3218720 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3218719 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3218714 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL3218729 | — | EC50 | = | 640.0 | nM | 6.19 |
| CHEMBL3218728 | — | EC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3218721 | — | EC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL3218716 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL3217766 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3218715 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3218717 | — | EC50 | = | 11350.0 | nM | 4.95 |
| CHEMBL3218718 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3218724 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3218725 | — | EC50 | > | 20000.0 | nM | - |