Assay Detail
Binding
CHEMBL3225202
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PARP1 in HEK293 cells assessed as prevention of in MNNG-induced ATP depletion
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.94 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219283 | — | — | 1 | 7.85 |
| CHEMBL45245 | — | — | 1 | 6.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219283 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL45245 | — | EC50 | = | 945.0 | nM | 6.03 |