Assay Detail
Binding
CHEMBL3225241
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Inhibition of human recombinant MAOB assessed as kynuramine conversion to 4-hydroxyquinoline after 20 mins by fluorescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.21 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3219619 | — | — | 1 | 7.28 |
| CHEMBL3219618 | — | — | 1 | 7.17 |
| CHEMBL1984524 | — | — | 1 | 6.85 |
| CHEMBL3219621 | — | — | 1 | 5.00 |
| CHEMBL3219620 | — | — | 1 | 4.75 |
| CHEMBL3219617 | — | — | 1 | - |
| CHEMBL402456 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3219619 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3219618 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL1984524 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3219621 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL3219620 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL3219617 | — | IC50 | = | 1300000.0 | nM | - |
| CHEMBL402456 | — | IC50 | = | 182000.0 | nM | - |