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Assay Detail

CHEMBL3225244

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human recombinant MAOA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of multifunctional small molecule-based reversible monoamine oxidase inhibitors
Geldenhuys WJ, Ko KS, Stinnett H, Van der Schyf CJ, Lim MH
Medchemcomm (2011) 2 : 1099 -1103
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 7 5.70 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3219618 1 7.00
CHEMBL3219619 1 6.72
CHEMBL1984524 1 5.64
CHEMBL3219620 1 5.60
CHEMBL3219621 1 5.29
CHEMBL402456 1 5.24
CHEMBL3219617 1 4.43

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3219618 Ki = 100.0 nM 7.00
CHEMBL3219619 Ki = 190.0 nM 6.72
CHEMBL1984524 Ki = 2300.0 nM 5.64
CHEMBL3219620 Ki = 2500.0 nM 5.60
CHEMBL3219621 Ki = 5100.0 nM 5.29
CHEMBL402456 Ki = 5700.0 nM 5.24
CHEMBL3219617 Ki = 37000.0 nM 4.43