Assay Detail
Functional
CHEMBL3225245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against liver stage of Plasmodium berghei sporozoites expressing firefly luciferase infected in human Huh7 cells assessed as inhibition of parasite development treated 1 hr prior to infection followed by compound replenisment at 24 hrs post-infection measured 48 hrs after infection by bioluminescence analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium berghei |
| Tissue | Liver |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.65 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3220026 | — | — | 1 | 5.86 |
| CHEMBL3220022 | — | — | 1 | 5.81 |
| CHEMBL3220023 | — | — | 1 | 5.79 |
| CHEMBL3220020 | — | — | 1 | 5.70 |
| CHEMBL3220021 | — | — | 1 | 5.67 |
| CHEMBL3220028 | — | — | 1 | 5.67 |
| CHEMBL3220029 | — | — | 1 | 5.65 |
| CHEMBL2316805 | — | — | 1 | 5.63 |
| CHEMBL3220024 | — | — | 1 | 5.63 |
| CHEMBL3220027 | — | — | 1 | 5.63 |
| CHEMBL3220025 | — | — | 1 | 5.62 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3220026 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL3220022 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL3220023 | — | IC50 | = | 1630.0 | nM | 5.79 |
| CHEMBL3220020 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL3220021 | — | IC50 | = | 2130.0 | nM | 5.67 |
| CHEMBL3220028 | — | IC50 | = | 2120.0 | nM | 5.67 |
| CHEMBL3220029 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL2316805 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL3220024 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL3220027 | — | IC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL3220025 | — | IC50 | = | 2390.0 | nM | 5.62 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 7500.0 | nM | 5.12 |