Assay Detail
Binding
CHEMBL3225722
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Time-dependent inhibition of Trypanosoma cruzi trypanothione reductase assessed as dissociation constants for enzyme-inhibitor binding using TS2 as substrate by DTNB-coupled assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses of a new class of phenyl butyraldehyde-derived amines with in vitro trypanocide activities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.75 | 4.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313792 | MELARSEN OXIDE | -1.0 | 1 | 4.75 |
| CHEMBL3221052 | — | — | 1 | - |
| CHEMBL3138643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313792 | MELARSEN OXIDE | Ki | = | 18000.0 | nM | 4.75 |
| CHEMBL3221052 | — | Ki | = | 288000.0 | nM | - |
| CHEMBL3138643 | — | Ki | = | 304000.0 | nM | - |