Assay Detail
Binding
CHEMBL3225723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Time-dependent inhibition of Trypanosoma cruzi trypanothione reductase assessed as stabilization of enzyme-inhibitor complexes using TS2 as substrate by DTNB-coupled assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Syntheses of a new class of phenyl butyraldehyde-derived amines with in vitro trypanocide activities
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.14 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313792 | MELARSEN OXIDE | -1.0 | 1 | 5.85 |
| CHEMBL3221052 | — | — | 1 | 4.43 |
| CHEMBL3138643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313792 | MELARSEN OXIDE | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL3221052 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL3138643 | — | Ki | = | 114000.0 | nM | - |