Assay Detail
Binding
CHEMBL3226699
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to adrenergic alpha1A receptor (unknown origin) by PDSP assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.05 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.00 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.00 |
| CHEMBL716 | QUETIAPINE | 4.0 | 1 | 7.00 |
| CHEMBL1112 | ARIPIPRAZOLE | 4.0 | 1 | 7.00 |
| CHEMBL3217984 | — | — | 1 | 6.30 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL85 | RISPERIDONE | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL716 | QUETIAPINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL1112 | ARIPIPRAZOLE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL3217984 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL715 | OLANZAPINE | Ki | = | 1000.0 | nM | 6.00 |